Cross cutting areas of research

Students in a labTheme: Cross cutting areas of research

The projects that fall under the four research themes are supported by these additional projects, studies and trials which provide scientific validation and benefit across more than one project, the so-called cross cutting activities, of which there are five:

A range of studies aimed to define the optimum dose for the candidate antimalarial drugs for the treatment and prevention trials and studies that measure drug levels achieved in pregnant women to help interpret the efficacy and tolerance data from the multicentre treatment and prevention trials.


A centralised pharmacovigilance database has been established at the Liverpool School of Tropical Medicine to record drug safety information relating to all drugs used in the MiP Consortium clinical trials and from observational sites as the projects progress.  This data is being used to provide better risk-benefit profiles for drugs used for the treatment and prevention of malaria in pregnancy.

Pathogenesis & Immunity
Laboratory studies to improve the interpretation of intervention trial results by factoring in host immunity, placental histology and parasite drug resistance, and to determine the impact of interventions on malaria immunity in the mother and infant.  Two cohort studies to better understand the relationship between when a pregnant woman becomes infected with malaria (e.g. in the 1st, 2nd or 3rd trimester) and the outcome of her pregnancy are also included (this will help to better target preventative treatment).

Capacity Development
Training for scientists, trial coordinators and monitors in endemic countries has been developed by a dedicated working group within the Consortium.  The investment in people and facilities as a result of all the Consortium activities will increase infrastructure capacity and help to develop a network of excellence in malaria in pregnancy research.

Policy Liaison Group
The main purpose of the MiP Policy liaison group is to ensure two way information exchange between the MiP Consortium and policy makers at global, regional and national levels. The RBM MiP Working group will be the main platform for the MiP Consortium to communicate to international and regional (and to some extent national) policy makers via their biannual meetings.