IST versus IPTp with SP in West Africa
Title: Intermittent preventive treatment with sulfadoxine-pyrimethamine versus intermittent screening and treatment of malaria in pregnancy
Principal Investigator: Prof. Brian Greenwood (UK)
Co-Principal investigator: Prof. Daniel Chandramohan (UK)
Trial Coordinator: Dr. Harry Tagbor (Ghana)
Dr. Pascal Magnussen (Denmark), Dr. Sheick Coulibaly, Dr Edgar Dabira (Burkina Faso), Dr. Kalifa Bojang, Dr. Khalifa Mohammed & Fanta Njie (The Gambia), Dr. Abraham Hodgson, Dr John Williams (Ghana), Dr. Kassoum Kayentao (Mali)
Study countries sites:
Burkina Faso (Ziniare), Ghana (Navrongo), Mali (San & Kita) and The Gambia (Basse).
The goal of this project is to determine whether screening and treatment for malaria at each scheduled antenatal clinic visit of pregnant women sleeping under a long lasting insecticide treated bed net is as effective in protecting them from anaemia, low birth weight and placental infection as Intermittent Preventive Treatment with sulphadoxine-pyrimethamine (SP-IPTp).
The incidence of malaria, in general and in pregnant women, is declining in many African countries. Consequently, there is a need to re-examine the efficacy and cost effectiveness of giving multiple intermittent preventive treatments with sulphadoxine-pyrimethamine during pregnancy (SP-IPTp). In addition, this intervention is threatened by increasing resistance to SP and potential alternatives to SP-IPTp need to be explored. This applies especially to areas with highly seasonal malaria transmission where women are at risk of malaria for only a short period during the year.
This study will provide information to national malaria control programmes on whether there are alternative, safe and effective strategies to the SP IPTp regimen for reducing the burden of malaria in pregnancy.
Two groups of 2,500 women, 5,000 overall, are being recruited in Burkina Faso, Mali and The Gambia. The trial started in June 2010., It is anticipated that recruitment will be completed by the end of December 2011 and that all field work will be completed by mid 2012.